Antimicrobial flavonoids from Psidia trinervia and their methylated and acetylated derivatives

Code (CO)	MSI99P0341
Author (AU)	Wang, Y. Hamburger, M. Guého, J. Hostettmann, K.
Title - English (ET)	Antimicrobial flavonoids from Psidia trinervia and their methylated and acetylated derivatives
Document Type(DT)	Periodical article
Date of publication (DP)	1989
Series (SE)	Phytochemistry
Source (SO)	28(9): 2323-2327
Language of text (LT)	En
Language of summaries (LS)	En
Abstract (AB)	From a dichloromethane extract and a hydrolysed methanolic extract from the leaves of Psiadia trinervia, 13 3-methylated flavonols have been isolated. Their s tructures were established by the usual spectroscopic methods (UV, EIMS, 1H and 13 C NMR). Ayanin, casticin, chrysosplenol-D and 5,7,4'-trihydroxy-3,8-dimethoxyflavone were responsible for the antifungal activity found in the preliminary screening. Chrysosplenol-D, isokaempferide, 5,7,4'-trihydroxy-3,3' dimethoxyflavone and 5,7,4'-trihydroxy-3,8-dimethoxyflavone displayed antibacterial activity. Twenty nine derivatives were prprepared by permethylation and selective methylation of the free hydroxyl group at C-5. The antimicrobial activities of the isolates and derivatives were determined by bioautographic assays using C. cucumerinum and B. cereus as test organisms.
Descriptors - English (DE)	FLAVONOIDS PSIADIA TRINERVIA ANTIINFECTIVE AGENTS ANTIFUNGAL AGENTS ESSENTIAL OIL PLANTS FLORA
Sort Key 1(K1)	Flora
Date record entered (DA)	1992-02-20
Language of analysis (LA)	En
Affiliation (AF)	Mauritius Sugar Industry Research Institute
Location (LO)	HERB
Processing status (PS)	CAT
Number of copies (NC)	1
MSIRI Staff (MS)	HERB